In a double-blind, multisite trial, they randomly assigned 400 patients
who had lumbar central spinal stenosis and moderate-to-severe leg pain
and disability to receive epidural injections of glucocorticoids plus
lidocaine or lidocaine alone. The patients received one or two
injections before the primary outcome evaluation, performed 6 weeks
after randomization and the first injection.
At 6 weeks, there were no significant between-group differences in the
RMDQ score (adjusted difference in the average treatment effect between
the glucocorticoid–lidocaine group and the lidocaine-alone group).
In the treatment of lumbar spinal stenosis, epidural injection of
glucocorticoids plus lidocaine offered minimal or no short-term benefit
as compared with epidural injection of lidocaine alone.