The objectives of this study were to assess the impact of mannitol on
the incidence and severity of acute kidney injury (AKI) and to identify risk factors and
outcome for AKI in patients with intracranial hemorrhage (ICH).
The authors retrospectively evaluated 153 adult patients who received
mannitol infusion after ICH between January 2005 and December 2009 in
the neurosurgical intensive care unit.
The overall incidence of AKI among study participants was 10.5%
Acute kidney injury occurred more frequently in patients who
received mannitol infusion at a rate ≥ 1.34 g/kg/day than it did in
patients who received mannitol infusion at a rate < 1.34 g/kg/day.
higher mannitol infusion rate was associated with more severe AKI.
Independent risk factors for AKI were mannitol infusion rate ≥ 1.34
g/kg/day, age ≥ 70 years, diastolic blood pressure (DBP) ≥ 110 mm Hg,
and glomerular filtration rate < 60 ml/min/1.73 m2