Sedation Depth During Spinal Anesthesia and Survival in Elderly Patients Undergoing Hip Fracture Repair Brown, Charles H. IV MD MHS; Azman, Andrew S. MS; Gottschalk, Allan MD, PhD Mears, Simon C. MD, PhD; Sieber, Frederick E. MD
Anesthesia & Analgesia:
Low intraoperative Bispectral Index (BIS) values may be associated with increased mortality. Among all patients, mortality was equivalent across sedation groups. However, among patients with serious comorbidities (Charlson score >4), 1-year mortality was reduced in the light (22.2%) vs deep (43.6%) sedation group (hazard ratio [HR], 0.43; 95% confidence interval, 0.19–0.97; P = 0.04) during spinal anesthesia. Similarly, among patients with Charlson score >6, 1-year mortality was reduced in the light (28.6%) vs deep (52.6%) sedation group (HR 0.33; 95% confidence interval, 0.12–0.94; P = 0.04) during spinal anesthesia.