Saturday, May 31, 2014

Effect of adding statins before surgery on mortality and major morbidity : a meta analysis
Joanne Guay et al

 Journal of Cardiothoracic and Vascular Anesthesia
Volume 28, Issue 2 , Pages 255-266, April 2014

 A search for all randomized controlled trials ,adult patients undergoing any type of procedure.
The search produced 29 trials.
Statins reduced the 0-30 days’ risk of myocardial infarction: risk ratio (RR) 0.48 (95%CI 0.38, 0.61); I-square 13.2%; p<0.001; number needed-to-treat 17 (14, 24)
There were no statistical differences at 0-30 days for stroke , acute renal insufficiency or reoperation. There was a trend for a reduced mortality at 1 year.

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