Comparative Analysis of Outcome Measures Used in Examining Neurodevelopmental Effects of Early Childhood Anesthesia Exposure
Ing, Caleb H. M.D., M.S.; DiMaggio, Charles J. Ph.D., M.P.H.,
P.A.-C.; Malacova, Eva Ph.D.; Whitehouse, Andrew J. Ph.D.; Hegarty, Mary
K. M.B.B.S., F.A.N.Z.C.A.; Feng, Tianshu M.S.; Brady, Joanne E. M.S.;
von Ungern-Sternberg, Britta S. M.D., Ph.D.; Davidson, Andrew J. M.D.;
Wall, Melanie M. Ph.D.; Wood, Alastair J. J. M.D.; Li, Guohua M.D.,
Dr.P.H.; Sun, Lena S. M.D.
Anesthesiology:
Of 781 children studied, 112 had anesthesia exposure. The incidence of
deficit ranged from 5.1 to 7.8% in neuropsychological tests, 14.6 to
29.5% in International Classification of Diseases, 9th Revision,
Clinical Modification–coded outcomes, and 4.2 to 11.8% in academic
achievement tests. Compared with unexposed peers, exposed children had
an increased risk of deficit in neuropsychological language assessments and International Classification of Diseases, 9th Revision, Clinical
Modification–coded language and cognitive disorders (adjusted risk
ratio, 1.57; 95% CI, 1.18 to 2.10), but not academic achievement scores.
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