Clonidine in Patients Undergoing Noncardiac Surgery

 P.J. Devereaux, M.D et al

N Engl J Med 2014; 370:1504-1513April 17, 2014

Administration of low-dose clonidine in patients undergoing noncardiac surgery did not reduce the rate of the composite outcome of death or nonfatal myocardial infarction; it did, however, increase the risk of clinically important hypotension and nonfatal cardiac arrest.